Recent Publications

Finley Lab Publications

2006 - 2012



Elsasser, S, Shi, Y, Finley, D (2012). Binding of ubiquitin conjugates to proteasomes as visualized with native gels. Methods Mol. Biol., 832:403-22.

Dimova, NV, Hathaway, NA, Lee, BH, Kirkpatrick, DS, Berkowitz, ML, Gygi, SP, Finley, D, King, RW (2012). APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1. Nat. Cell Biol., 14, 2:168-76.

Tian, G, Finley, D (2012). Cell biology: Destruction deconstructed. Nature, 482, 7384:170-1.

Nag, DK, Finley, D (2012). A small-molecule inhibitor of deubiquitinating enzyme USP14 inhibits Dengue virus replication. Virus Res., 165, 1:103-6.



Tian, G, Park, S, Lee, MJ, Huck, B, McAllister, F, Hill, CP, Gygi, SP, Finley, D (2011). An asymmetric interface between the regulatory and core particles of the proteasome. Nat. Struct. Mol. Biol., 18, 11:1259-67.

Park, S, Kim, W, Tian, G, Gygi, SP, Finley, D (2011). Structural defects in the regulatory particle-core particle interface of the proteasome induce a novel proteasome stress response. J. Biol. Chem., 286, 42:36652-66.

Chen, PC, Bhattacharyya, BJ, Hanna, J, Minkel, H, Wilson, JA, Finley, D, Miller, RJ, Wilson, SM (2011). Ubiquitin homeostasis is critical for synaptic development and function. J. Neurosci., 31, 48:17505-13.

Dange, T, Smith, D, Noy, T, Rommel, PC, Jurzitza, L, Cordero, RJ, Legendre, A, Finley, D, Goldberg, AL, Schmidt, M (2011). Blm10 protein promotes proteasomal substrate turnover by an active gating mechanism. J. Biol. Chem., 286, 50:42830-9.

Finley, D (2011). Misfolded proteins driven to destruction by Hul5. Nat. Cell Biol., 13, 11:1290-2.



Lee, BH, Lee, MJ, Park, S, Oh, DC, Elsasser, S, Chen, PC, Gartner, C, Dimova, N, Hanna, J, Gygi, SP, Wilson, SM, King, RW, Finley, D (2010). Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature, 467, 7312:179-84.

Lee, MJ, Lee, BH, Hanna, J, King, RW, Finley, D (2011). Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes. Mol. Cell Proteomics, 10, 5:R110.003871.

Isasa, M, Katz, EJ, Kim, W, Yugo, V, González, S, Kirkpatrick, DS, Thomson, TM, Finley, D, Gygi, SP, Crosas, B (2010). Monoubiquitination of RPN10 regulates substrate recruitment to the proteasome. Mol. Cell, 38, 5:733-45.

Chen, X, Lee, BH, Finley, D, Walters, KJ (2010). Structure of proteasome ubiquitin receptor hRpn13 and its activation by the scaffolding protein hRpn2. Mol. Cell, 38, 3:404-15.

Park, S, Tian, G, Roelofs, J, Finley, D (2010). Assembly manual for the proteasome regulatory particle: the first draft. Biochem. Soc. Trans., 38, Pt 1:6-13.



Finley, D (2009). Recognition and processing of ubiquitin-protein conjugates by the proteasome. Annu. Rev. Biochem., 78:477-513.

Zhang, F, Wu, Z, Zhang, P, Tian, G, Finley, D, Shi, Y (2009). Mechanism of substrate unfolding and translocation by the regulatory particle of the proteasome from Methanocaldococcus jannaschii. Mol. Cell, 34, 4:485-96.

Zhang, F, Hu, M, Tian, G, Zhang, P, Finley, D, Jeffrey, PD, Shi, Y (2009). Structural insights into the regulatory particle of the proteasome from Methanocaldococcus jannaschii. Mol. Cell, 34, 4:473-84.

Park, S, Roelofs, J, Kim, W, Robert, J, Schmidt, M, Gygi, SP, Finley, D (2009). Hexameric assembly of the proteasomal ATPases is templated through their C termini. Nature, 459, 7248:866-70.

Roelofs, J, Park, S, Haas, W, Tian, G, McAllister, FE, Huo, Y, Lee, BH, Zhang, F, Shi, Y, Gygi, SP, Finley, D (2009). Chaperone-mediated pathway of proteasome regulatory particle assembly. Nature, 459, 7248:861-5.

Xu, P, Duong, DM, Seyfried, NT, Cheng, D, Xie, Y, Robert, J, Rush, J, Hochstrasser, M, Finley, D, Peng, J (2009). Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation. Cell, 137, 1:133-45.



Schreiner, P, Chen, X, Husnjak, K, Randles, L, Zhang, N, Elsasser, S, Finley, D, Dikic, I, Walters, KJ, Groll, M (2008). Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction. Nature, 453, 7194:548-52.

Husnjak, K, Elsasser, S, Zhang, N, Chen, X, Randles, L, Shi, Y, Hofmann, K, Walters, KJ, Finley, D, Dikic, I (2008). Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature, 453, 7194:481-8.

Goh, AM, Walters, KJ, Elsasser, S, Verma, R, Deshaies, RJ, Finley, D, Howley, PM (2008). Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins. BMC Biochem., 9:4.



Kleijnen, MF, Roelofs, J, Park, S, Hathaway, NA, Glickman, M, King, RW, Finley, D (2007). Stability of the proteasome can be regulated allosterically through engagement of its proteolytic active sites.Nat. Struct. Mol. Biol., 14, 12:1180-8.

Smith, DM, Chang, SC, Park, S, Finley, D, Cheng, Y, Goldberg, AL (2007). Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry.Mol. Cell, 27, 5:731-44.

Hanna, J, Meides, A, Zhang, DP, Finley, D (2007). A ubiquitin stress response induces altered proteasome composition. Cell, 129, 4:747-59.

Hanna, J, Finley, D (2007). A proteasome for all occasions. FEBS Lett., 581, 15:2854-61.



Crosas, B, Hanna, J, Kirkpatrick, DS, Zhang, DP, Tone, Y, Hathaway, NA, Buecker, C, Leggett, DS, Schmidt, M, King, RW, Gygi, SP, Finley, D (2006). Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities. Cell, 127, 7:1401-13.

Hanna, J, Hathaway, NA, Tone, Y, Crosas, B, Elsasser, S, Kirkpatrick, DS, Leggett, DS, Gygi, SP, King, RW, Finley, D (2006). Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation. Cell, 127, 1:99-111.

Kirkpatrick, DS, Hathaway, NA, Hanna, J, Elsasser, S, Rush, J, Finley, D, King, RW, Gygi, SP (2006). Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology. Nat. Cell Biol., 8, 7:700-10.