Recent Publications

Selected Finley Lab Publications

2006-2017

2017

Nguyen AT*, Prado MA*, Schmidt PJ, Sendamarai AK, Wilson-Grady JT, Min M, Campagna DR, Tian G, Shi Y, Dederer V, Kawan M, Kuehnle N, Paulo JA, Yao Y, Weiss MJ, Justice MJ, Gygi SP, Fleming MD and Finley D (2017). "UBE2O remodels the proteome during terminal erythroid differentiation." Science 357(6350). PMID: 28774900.

 

2016

Lee BH, Lu Y, Prado MA, Shi Y, Tian G, Sun S, Elsasser S, Gygi SP, King RW and Finley D (2016). "USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites." Nature 532(7599): 398-401. PMID: 27074503.

Choi WH, de Poot SA, Lee JH, Kim JH, Han DH, Kim YK, Finley D and Lee MJ (2016). "Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation." Nat Commun 7: 10963. PMID: 26957043.

Shi Y*, Chen X*, Elsasser S*, Stocks BB*, Tian G, Lee BH, Shi Y, Zhang N, de Poot SA, Tuebing F, Sun S, Vannoy J, Tarasov SG, Engen JR, Finley D and Walters KJ (2016). "Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome." Science 351(6275). PMID: 26912900.

Finley D, Chen X and Walters KJ (2016). "Gates, Channels, and Switches: Elements of the Proteasome Machine." Trends Biochem Sci 41(1): 77-93. PMID: 26643069.

 

2015

Xu D, Shan B, Lee BH, Zhu K, Zhang T, Sun H, Liu M, Shi L, Liang W, Qian L, Xiao J, Wang L, Pan L, Finley D and Yuan J (2015). "Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system." Elife 4: e10510. PMID: 26523394.

Isasa M, Rose CM, Elsasser S, Navarrete-Perea J, Paulo JA, Finley DJ and Gygi SP (2015). "Multiplexed, Proteome-Wide Protein Expression Profiling: Yeast Deubiquitylating Enzyme Knockout Strains." J Proteome Res 14(12): 5306-5317. PMID: 26503604.

Lu Y, Lee BH, King RW, Finley D and Kirschner MW (2015). "Substrate degradation by the proteasome: a single-molecule kinetic analysis." Science 348(6231): 1250834. PMID: 25859050.

 

2014

King RW and Finley D (2014). "Sculpting the proteome with small molecules." Nat Chem Biol 10(11): 870-874. PMID: 25325686.

 

2013

Park S, Li X, Kim HM, Singh CR, Tian G, Hoyt MA, Lovell S, Battaile KP, Zolkiewski M, Coffino P, Roelofs J, Cheng Y and Finley D (2013). "Reconfiguration of the proteasome during chaperone-mediated assembly." Nature 497(7450): 512-516. PMID: 23644457.

 

2012

Finley D, Ulrich HD, Sommer T and Kaiser P (2012). "The ubiquitin-proteasome system of Saccharomyces cerevisiae." Genetics 192(2): 319-360. PMID: 23028185.

Elsasser S, Shi Y and Finley D (2012). "Binding of ubiquitin conjugates to proteasomes as visualized with native gels." Methods Mol Biol 832: 403-422. PMID: 22350901.

Dimova NV, Hathaway NA, Lee BH, Kirkpatrick DS, Berkowitz ML, Gygi SP, Finley D and King RW (2012). "APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1." Nat Cell Biol 14(2): 168-176. PMID: 22286100.

Tian G and Finley D (2012). "Cell biology: Destruction deconstructed." Nature 482(7384): 170-171. PMID: 22318600.

Nag DK and Finley D (2012). "A small-molecule inhibitor of deubiquitinating enzyme USP14 inhibits Dengue virus replication." Virus Res 165(1): 103-106. PMID: 22306365.

 

2011

Tian G, Park S, Lee MJ, Huck B, McAllister F, Hill CP, Gygi SP and Finley D (2011). "An asymmetric interface between the regulatory and core particles of the proteasome." Nat Struct Mol Biol 18(11): 1259-1267. PMID: 22037170.

Park S, Kim W, Tian G, Gygi SP and Finley D (2011). "Structural defects in the regulatory particle-core particle interface of the proteasome induce a novel proteasome stress response." J Biol Chem 286(42): 36652-36666. PMID: 21878652.

Chen PC, Bhattacharyya BJ, Hanna J, Minkel H, Wilson JA, Finley D, Miller RJ and Wilson SM (2011). "Ubiquitin homeostasis is critical for synaptic development and function." J Neurosci 31(48): 17505-17513. PMID: 22131412.

Dange T, Smith D, Noy T, Rommel PC, Jurzitza L, Cordero RJ, Legendre A, Finley D, Goldberg AL and Schmidt M (2011). "Blm10 protein promotes proteasomal substrate turnover by an active gating mechanism." J Biol Chem 286(50): 42830-42839. PMID: 22025621.

Finley D (2011). "Misfolded proteins driven to destruction by Hul5." Nat Cell Biol 13(11): 1290-1292. PMID: 21983564.

Lee MJ, Lee BH, Hanna J, King RW and Finley D (2011). "Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes." Mol Cell Proteomics 10(5): R110 003871. PMID: 20823120.

 

2010

Lee BH*, Lee MJ*, Park S, Oh DC, Elsasser S, Chen PC, Gartner C, Dimova N, Hanna J, Gygi SP, Wilson SM, King RW and Finley D (2010). "Enhancement of proteasome activity by a small-molecule inhibitor of USP14." Nature 467(7312): 179-184. PMID: 20829789.

Isasa M, Katz EJ, Kim W, Yugo V, Gonzalez S, Kirkpatrick DS, Thomson TM, Finley D, Gygi SP and Crosas B (2010). "Monoubiquitination of RPN10 regulates substrate recruitment to the proteasome." Mol Cell 38(5): 733-745. PMID: 20542005.

Chen X, Lee BH, Finley D and Walters KJ (2010). "Structure of proteasome ubiquitin receptor hRpn13 and its activation by the scaffolding protein hRpn2." Mol Cell 38(3): 404-415. PMID: 20471946.

Park S, Tian G, Roelofs J and Finley D (2010). "Assembly manual for the proteasome regulatory particle: the first draft." Biochem Soc Trans 38(Pt 1): 6-13. PMID: 20074027.

 

2009

Finley D (2009). "Recognition and processing of ubiquitin-protein conjugates by the proteasome." Annu Rev Biochem 78: 477-513. PMID: 19489727.

Zhang F, Wu Z, Zhang P, Tian G, Finley D and Shi Y (2009). "Mechanism of substrate unfolding and translocation by the regulatory particle of the proteasome from Methanocaldococcus jannaschii." Mol Cell 34(4): 485-496. PMID: 19481528.

Zhang F, Hu M, Tian G, Zhang P, Finley D, Jeffrey PD and Shi Y (2009). "Structural insights into the regulatory particle of the proteasome from Methanocaldococcus jannaschii." Mol Cell 34(4): 473-484. PMID: 19481527.

Park S, Roelofs J, Kim W, Robert J, Schmidt M, Gygi SP and Finley D (2009). "Hexameric assembly of the proteasomal ATPases is templated through their C termini." Nature 459(7248): 866-870. PMID: 19412160.

Roelofs J, Park S, Haas W, Tian G, McAllister FE, Huo Y, Lee BH, Zhang F, Shi Y, Gygi SP and Finley D (2009). "Chaperone-mediated pathway of proteasome regulatory particle assembly." Nature 459(7248): 861-865. PMID: 19412159.

Xu P, Duong DM, Seyfried NT, Cheng D, Xie Y, Robert J, Rush J, Hochstrasser M, Finley D and Peng J (2009). "Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation." Cell 137(1): 133-145. PMID: 19345192.

 

2008

Schreiner P*, Chen X*, Husnjak K*, Randles L, Zhang N, Elsasser S, Finley D, Dikic I, Walters KJ and Groll M (2008). "Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction." Nature 453(7194): 548-552. PMID: 18497827.

Husnjak K*, Elsasser S*, Zhang N*, Chen X, Randles L, Shi Y, Hofmann K, Walters KJ, Finley D and Dikic I (2008). "Proteasome subunit Rpn13 is a novel ubiquitin receptor." Nature 453(7194): 481-488. PMID: 18497817.

Goh AM, Walters KJ, Elsasser S, Verma R, Deshaies RJ, Finley D and Howley PM (2008). "Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins." BMC Biochem 9: 4. PMID: 18234089.

 

2007

Kleijnen MF, Roelofs J, Park S, Hathaway NA, Glickman M, King RW and Finley D (2007). "Stability of the proteasome can be regulated allosterically through engagement of its proteolytic active sites." Nat Struct Mol Biol 14(12): 1180-1188. PMID: 18026118.

Smith DM, Chang SC, Park S, Finley D, Cheng Y and Goldberg AL (2007). "Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry." Mol Cell 27(5): 731-744. PMID: 17803938.

Hanna J, Meides A, Zhang DP and Finley D (2007). "A ubiquitin stress response induces altered proteasome composition." Cell 129(4): 747-759. PMID: 17512408. 

Hanna J and Finley D (2007). "A proteasome for all occasions." FEBS Lett 581(15): 2854-2861. PMID: 17418826.

 

2006

Crosas B, Hanna J, Kirkpatrick DS, Zhang DP, Tone Y, Hathaway NA, Buecker C, Leggett DS, Schmidt M, King RW, Gygi SP and Finley D (2006). "Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities." Cell 127(7): 1401-1413. PMID: 17190603.

Hanna J, Hathaway NA, Tone Y, Crosas B, Elsasser S, Kirkpatrick DS, Leggett DS, Gygi SP, King RW and Finley D (2006). "Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation." Cell 127(1): 99-111. PMID: 17018280.

Kirkpatrick DS, Hathaway NA, Hanna J, Elsasser S, Rush J, Finley D, King RW and Gygi SP (2006). "Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology." Nat Cell Biol 8(7): 700-710. PMID: 16799550.